Most users should start by considering 75%. It keeps a full F row, independent arrow keys, and a compressed navigation column while saving approximately 1.5 inches of desk width compared to TKL. For gamers, programmers, and students, the functional loss is minimal and the space gain is real.
TKL genuinely wins for heavy keyboard navigation in Excel, Word, and long documents. If Home, End, PgUp, and PgDn get used dozens of times per hour, TKL's independent nav cluster has zero learning curve; 75%'s compressed right column can stay awkward.
TKL also wins for keycap compatibility. TKL uses fully standard keycap sizes. 75% right-column keys use non-standard sizes, and many popular keycap sets do not include them.
Not sure? Start with 75%. If you live in Excel or care about keycap sets, choose TKL.